The reported figure
Jastreboff et al. reported a 24.2% mean body-weight reduction at week 48 for the highest tested retatrutide arm in 338 adults with obesity or overweight plus a weight-related condition, excluding diabetes. Jastreboff et al., New England Journal of Medicine, 2023 ↗
The trial question
The ICH E9(R1) guideline defines an estimand as the precise treatment effect that a clinical trial aims to estimate. ICH E9(R1) estimands guideline ↗