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Evidence note

NNMT inhibition and the NAD salvage pathway

Neelakantan et al. reported increased NAD+ and SAM in differentiated adipocytes and reduced adiposity in diet-induced-obese mice.

Neelakantan et al., Biochemical Pharmacology, 2018 ↗

The cellular finding

Neelakantan et al. reported increased NAD+ and SAM in differentiated adipocytes after NNMT-inhibitor experiments. Neelakantan et al., Biochemical Pharmacology, 2018 ↗

The mouse finding

Neelakantan et al. reported reduced adiposity in diet-induced-obese mice in the same research programme. Neelakantan et al., Biochemical Pharmacology, 2018 ↗

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