Evidence profile
MOTS-c
MOTS-c study rows link each listed finding to its source, model or population, and endpoint.
Cited headline finding
The study reported folate-cycle and AMPK findings alongside mouse metabolic observations. ↗
Murine skeletal muscle, myotubes, and mouse diet/age modelsLee et al., Cell Metabolism 2015Animal
Mechanism scope
How cited research characterizes MOTS-c
Lee et al. reported folate-cycle and AMPK findings in murine skeletal muscle, myotubes, and mouse metabolic models.
Sources: Lee et al., Cell Metabolism 2015 ↗
Open question
What the cited MOTS-c sources do not resolve
The cited MOTS-c study does not establish findings beyond its murine and cell-culture systems.
Sources: Lee et al., Cell Metabolism 2015 ↗
| Finding | Year | n | Model or population | Endpoint | Source | Evidence tier |
|---|---|---|---|---|---|---|
| The study reported folate-cycle and AMPK findings alongside mouse metabolic observations. | 2015 | Not stated | Murine skeletal muscle, myotubes, and mouse diet/age models | Glucose uptake, AMPK signalling, insulin sensitivity, and metabolic observations | Lee et al., Cell Metabolism 2015 ↗ | Animal |
Regulatory status
MOTS-C appears in Health Canada's peptide-drug advisory. ↗
Reviewer: Ember Peptides source-verification editorial review · Review date: 2026-09-13